Richard Wolf China

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System Blue

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Photodynamic diagnosis is an endourological technique for the early diagnosis of non-muscle-invasive bladder cancer (NMIBC). It has been widely used for many years to reduce the risk of NMIBC progression and recurrence.

With attention to every detail, Richard Wolf has developed a precise photodynamic diagnosis (BLC) system – System Blue – that sets a new benchmark in diagnosing bladder cancer with Hexvix®. The system components are perfectly matched to the photosensitizer, significantly improving tumor fluorescence and therefore the detection rate.

Brochure

Carcinoma in situ (CIS, pTis)

Papillary carcinoma (pTa)

White light image

In conventional cystoscopy, early bladder cancer is easily overlooked because of its flat growth or small size.

Carcinoma in situ (CIS, pTis) in blue light SIM mode

Papillary carcinoma (pTa) in blue light mode

Blue light SIM mode

In blue light mode, tumor tissue fluoresces red. The rest of the bladder wall appears bright and high in contrast, so the whole bladder is clearly visible.

Carcinoma in situ (CIS, pTis) in blue light color contrast SIM mode

Papillary carcinoma (pTa) in blue light color contrast mode

Blue light color contrast SIM mode

In blue light color contrast mode, tumor fluorescence appears bright magenta.

A comparison of xenon technology and the ENDOLIGHT LED blue with the absorption spectrum shows that the emission band of the ENDOLIGHT LED blue light source is perfectly matched to the main absorption band of Hexvix® (PPIX), producing stronger tumor fluorescence.

Platform and components

ENDOCAM Logic 4K camera controller

Sharp 4K resolution of up to 4096 × 2160 pixels
Compatible with all applied parts and camera heads of the ENDOCAM Logic HD
Special Imaging Modes (SIM) for image differentiation
Very easy to use, with clinical presets for each discipline
Default user settings saved automatically
High-resolution images and videos stored on USB media
Compatible with the core nova integrated operating room

ENDOCAM Logic 4k

PENDUAL blue HD camera head

Camera head rotates flexibly between 0° and 90° for intuitive handling
1080p Full HD sensor resolution
Also suitable for white light endoscopy

PENDUAL blue HD camera head

ENDOLIGHT LED blue

LED blue light source
Constant illumination throughout its service life
Very high color contrast for effective differentiation of tumor tissue
Also suitable for white light endoscopy

Light Sources

PANOVIEW blue telescopes

Telescopes deliver bright, vivid images
New fiber design for improved transmission
Also suitable for white light endoscopy

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Special blue fiber optic light cable

Autoclavable, extra-soft light cable designed for fluorescence applications
Optimized fiber design for improved transmission
Also suitable for white light endoscopy

About Hexvix

Hexvix® with blue light cystoscopy – for precise diagnosis and treatment of bladder cancer

Hexvix® (hexaminolevulinate) combined with the Richard Wolf blue light cystoscopy system enhances the visual identification of bladder tumor lesions through photodynamic diagnosis (PDD), providing an integrated drug-and-device solution for the precise diagnosis and treatment of non-muscle-invasive bladder cancer (NMIBC).

After intravesical instillation of Hexvix®, tumor tissue shows a characteristic red fluorescence under blue light, in clear contrast to normal mucosa. This helps physicians find small, flat and carcinoma in situ (CIS) lesions that are easily missed under white light, and identify residual lesions during TURBT, improving the completeness of tumor resection.

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In a Chinese bridging Phase III study, Hexvix® with blue light cystoscopy detected at least one additional bladder cancer lesion not seen under white light in 43.3% of patients, and further increased the detection rate of CIS.

Resect more completely 

Blue light helps identify residual lesions easily missed under white light, improving the completeness of TURBT and reducing the risk of residual tumor after surgery.

Fewer recurrences 

Clinical studies show that blue light cystoscopy-guided TURBT reduces the risk of recurrence in NMIBC patients and prolongs recurrence-free survival.

Longer follow-up 

Long-term follow-up studies show that blue light cystoscopy reduces the need for repeat TURBT, bringing lasting benefits for the long-term management of NMIBC.

Hexvix®  

From lesion detection to precise resection, clearer visualization helps make NMIBC diagnosis and treatment more precise.

Procedure for BLC with System Blue

Opinions and views

Michael Straub, MD

Head of Endourology, Department of Urology, Klinikum rechts der Isar, Technical University of Munich

"Thanks to the HD images, tumors are easy to distinguish even in white light mode, and the different blue BLC modes offer excellent differentiation and high contrast. In short, this is a huge step forward from what we knew before."

Gerson Lüdecke, MD

Senior Physician, Uro-Oncology, Clinic for Urology and Andrology, Giessen, Germany

"The great thing about System Blue is its powerful image illumination: it lets me work continuously in BLC mode without changing optics and completely resect all tumors with a high degree of clinical safety."

Shahrokh F. Shariat, MD

Professor and Chairman, Department of Urology and Comprehensive Cancer Center, Vienna General Hospital, Medical University of Vienna

"In my personal experience, every improvement in image quality contributes to successful treatment outcomes by improving the detectability of tumor tissue. That is a great benefit for patients."

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